A100x Ventures is a New York-based early-stage venture capital firm, founded in 2020/2021, co-led by managing partners Nisa Amoils and Sal Ternullo. The firm specializes in backing pre-seed and seed-stage startups operating at the intersection of artificial intelligence and blockchain technologies. A100x employs a thesis-driven approach, focusing on real-world applications that leverage emerging technologies to reshape industries such as decentralized finance (DeFi), digital identity, enterprise infrastructure, healthcare, climate, food and drug supply chains, and broader financial services. They aim to support founders building middleware and applications that solve real-world challenges and foster enterprise and consumer adoption of these technologies, steering past speculation and hype.